• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Activator unit for an auto-injector with a we ..: ... Sent cylindrical housing (3) in which an axially displaceable pressure pin (4) is guided, which against a spring unit inserted and in the inserted position by means of locking projections (6) one with the pressure pin connected to the support member (5) is lockable, wherein the Federeinhei t comprises a first coil spring (1) and at least one further second coil spring (2) having a larger diameter than the first coil spring, wherein the second coil spring is arranged coaxially to the first coil spring ,
    公开号:AT514484A1
    申请号:T514/2013
    申请日:2013-06-24
    公开日:2015-01-15
    发明作者:
    申请人:Pharma Consult Gmbh；
    IPC主号:
    专利说明:

    SCHÜTZ u. PARTNER ': ".:' · &Quot; :::::. «···········································································································································································
    EUROPEAN PATENT AND TRADEMARK ATTORNEYS A- 1200 VIENNA, BRIGITTENAUER COUNTRIES 50 PHONE: (+43 1) 532 41 30-0 DIPL.-ING. WALTER WOODEN TELEFAX: (+43 1) 532 41 31
    DIPL-ING. DR. TECHN. ELISABETH SCHOBER E-MAIL: MAILOPATENT.AT
    The invention relates to an activator unit for an autoinjector with a substantially cylindrical housing, in which an axially displaceable pressure pin is guided, which can be inserted against a spring unit and locked in the inserted position by means of latching extensions of a holding element connected to the pressure pin. The invention also relates to an autoinjector with the activator unit.
    Activators of the type mentioned are used as part of medical syringes, which are simple, automatic and mostly unique to use. Such a syringe, referred to as an autoinjector, is placed at its distal end on a region of interest of the human body and subsequently triggered in the proximal region of the autoinjector by a simple handle. The terms "proximal" and "distal" refer to the perspective of the user of an auto-injector.
    WO 2005/021070 A1 shows a device for the automatic injection of injection fluids. A part of this device is also an activator in a cylindrical housing in which a piston rod is slidable by a spring. When the spring is released and the piston rod is subsequently pushed out to the distal end of the activator, a carpule is connected to an injection needle, the needle is pushed out of the automatic injection device and the piston rod is pressed into the carpule so that a liquid medicament is injected through the needle becomes. Optionally, the needle may already be connected to the carpule. A disadvantage of this teaching is that the energy storage of the activator consists of a coil spring. As a result, the force required to inject the liquid can be communicated only at the end of the automatic injection process and thus by the coil spring in the almost relaxed state. The available power is indeed sufficient to squeeze a liquid drug through the cannula. However, it is no longer sufficient to force a viscous drug through the cannula and / or drug through a smaller diameter cannula.
    The invention aims to provide an activator as set forth above, which exerts a higher force when the drug is to be injected. Furthermore, the activator should not be much more expensive and expensive to produce than activators of the prior art; it should also be easy and safe to use compared to the prior art activators, as well as having no larger external dimensions. Another object is to make the operation of an auto-injector more comfortable for the patient.
    The activator according to the invention achieves this by virtue of the fact that the spring unit comprises a first spiral spring and at least one further second spiral spring having a larger diameter than the first spiral spring, wherein the second spiral spring is arranged coaxially with the first spiral spring. A piston rod extending from the piston to the proximal end of the activator is no longer provided.
    A preferred embodiment of the activator unit is characterized in that the first coil spring and the second coil spring have substantially the same length.
    In one embodiment of the invention, the first coil spring and the second coil spring are designed as parts of a one-piece double spring.
    To further embodiment of the invention, the second coil spring is held and locked with a displaceable by the first coil spring member, wherein the locking of the second coil spring at an outer relaxation point of the first coil spring can be unlocked.
    In another embodiment of the invention, the first coil spring is held and locked with a displaceable by the second coil spring member, the Verrie gelung the first coil spring in an outer relaxation point of the second coil spring can be unlocked.
    In one embodiment of the invention, it is preferred that the activator unit has an activator sleeve displaceable in the axial direction, by means of which the latching extensions are displaceable in such a way that the latch is releasably movable and the pressure bolt can be moved by the spring unit.
    It is further preferred in an embodiment of the device according to the invention that the activator unit has a removable safety cap which has an organ which fixes the latching projections.
    In one embodiment of the invention, the activator unit has at its distal end a thread or a bayonet closure through which it can be connected to an injector unit.
    It is preferred in one embodiment of the invention that the pressure pin has on its distal end face mechanical means for breaking a seal.
    The invention also relates to an auto-injector having an activator unit according to the invention.
    The invention will be explained in more detail with reference to an embodiment shown in the drawings. 1 shows a cross section through an autoinjector, FIG. 2 shows an exploded view of the activator unit, and FIGS. 3 to 6 show schematic cross sections through an autoinjector.
    According to FIG. 1, an autoinjector has an injection unit 9 at its distal end. In it are a carpule 11, which carries the drug in itself, and the needle 12. The carpule 11 is closed at its distal end with a Karpu-lenversiegelung 16. At its proximal end, the carpule 11 has a pressure pin 4, which is displaceable into the carpule. The needle 12 is supported via a needle holder 13. At the proximal end of the autoinjector is the activator unit. It is bolted or otherwise connected to the injection unit 9 and shown in the secured state, as shown in FIG. a first coil spring 1 and a second coil spring 2 are in the tensioned state between a piston 15 at the distal end and a locking at the proximal end. In order to maintain the lock, a support member 5 holds the piston 15 via latching extensions 6 firmly. The respective displacement of the latching projections 6 along the direction of the longitudinal axis of the activator unit is prevented by a safety cap 8, which centrally has a pin which restricts the freedom of movement of the latching supports 6. Furthermore, an activator sleeve 7 is located circumferentially on the housing 3 of the activator unit and is displaceable toward the distal end of the activator unit and to the autoinjector as a whole. In the prior art it has not been possible to accommodate both a first spiral spring 1 and a second spiral spring 2 in the activator unit. The reason for this was that the autoinjector as a whole and the activator unit must form a handy instrument and therefore the space in the activator unit is very limited. Since auto-injectors were previously borrowed from conventional hypodermic syringes, a coil spring has been placed inside the hollow piston rod or within the cavity within the coil spring. Since the piston rod in turn claimed space, therefore, only space for a spring and thus a natural upper limit for the available pressure on the piston was set. The omission of the piston rod has not been considered, because thereby the mechanical elements, especially in the course of motion, would have received uncontrollable degrees of freedom. According to the invention, but at the same time the long piston rod is removed and occupied space occupied by a second coil spring. The resulting surprising effect is that the springs lead each other both in the cocked locked state and during the injection process and a movement only in the direction of relaxation, i. in the direction of the distal end of the activator, is possible. In this way, it is possible to substantially increase the spring force on pressure pin 4 and piston 15, but not to change the size of the Aktivatoreinheit in their outer dimensions substantially.
    In Fig. 2 it is shown how the previous piston, consisting of distal piston end and piston rod, only by the simple piston 15 shown in FIG. 2 is replaced. The support member 5 is inserted through the first coil spring 1 and the second coil spring 2 and locked at a proximal opening in the housing 3. Both springs sit on the piston 15 via a spring adapter 17. On the housing 3 then only the activator sleeve 7 and the fuse cap 8 is inserted. The activator unit which can be produced and stored separately from the injection unit 9 need not be sterile. Only at the moment of injection, the piston 15 presses on the pressure pin 4 of the injection unit 9; Before that, the piston 15 is locked in the activator unit and the pressure pin 5 is mounted inside the carpule 11 in the sterile injection unit 9. To improve the sterility requirements for the injection unit 9, it is sealed at its proximal end by a thin foil of suitable material. Also, while the activator unit is connected to the injection unit 9, the seal remains upright because the pressure pins 4 and pistons 15 are spaced from each other. However, it is advantageous for the smooth running when the piston 15 has a mechanical means for breaking the seal. This means may be, for example, that the piston 15 has at its distal end face a ring or other geometric arrangement of teeth, which slit the foil-like seal at the beginning of the injection process.
    3 shows an autoinjector with the activator unit according to the invention and the injection unit 9 connected to it in the starting position. The carpule 11 is sealed and not yet connected to the needle 12. The first coil spring 1 and the second coil spring 2 are tensioned and locked by the support member 5 which is fixed by the safety cap 8.
    Figs. 4, 5 and 6 show the sequence of injection based on three states of the auto-injector. In Fig. 4, the protective cap 8 is already removed and the activator sleeve 7 is displaced in the distal direction. In this case, the auto-injector is placed, for example, at its distal end on a body part of a patient (not shown). By moving the activator sleeve 7, the latching projections 6 of the support member 5 were compressed, which cancels the lock. The first coil spring 1 and the second coil spring 2 begin to relax. In this case, pressure is exerted on the piston 15, which begins to move in the distal direction. This initially causes it to touch down on the pressure pin 4 and also brings this in motion. The injection unit 9 is now set so that the pressure pin 4 does not move in the carpule 11, but carries the carpule 11 and presses against the needle 12. This now pierces through the cartridge seal 16 and connects to the carpule 11 itself.
    After complete connection of the needle 12 to the carpule 11, the pressure bolt 4, the carpule 11, together with the medicament and the needle 12, are now moved further in the distal direction by the spring pressure of both the first coil spring 1 and the second coil spring 2. A possible sealing of the injection unit 9 at its distal end is pierced by the needle 12, and the needle 12 penetrates into the body part of the patient. Since now the needle holder 13 and the carpule 11 arrive at its distal end point and come to a standstill in the injection unit 9, continues the existing pressure of the first coil spring 1 and the second coil spring 2 via the piston 15 on the pressure pin 4 to the fact that now Drug is injected via the needle 12. In this last step, the high pressure force of two parallel acting springs unfolds.
    FIG. 6 shows the end position of the autoinjector with the injection unit 9 and the activator unit according to the invention. Both the first coil spring 1 and the second coil spring 2 have moved the pressure pin 4 to the distal end of the carpule 11. The drug is now completely injected.
    In the embodiment of the autoinjector shown in the figures with the activator unit according to the invention, both springs operate simultaneously. It is also possible by known in the art telescopic sleeves to achieve a serial movement of the first coil spring 1 and the second coil spring 2. In such an embodiment, the first coil spring 1 pushes the carpule 11 and the needle 12 and the second coil spring 2 in the distal direction. During this process, the second coil spring 2 is locked with an organ and held in this. This organ may be a corresponding telescopic sleeve. The unlocking of the second coil spring 2 takes place shortly before or exactly when the carpule 11 together with the needle 12 have reached their maximum distal point. At this moment, the second coil spring 2 applies the force to expel the drug. An advantage of this embodiment is that a again increased force is available for the expulsion of the drug. It is also possible, conversely, to shift the first spring 1 locked by the second spring 2, which has already been triggered first, to the distal end and to release the first spring 1 only when the carpule 11 and needle 12 have arrived at the distal end of the autoinjector or are about to reach it.
    The staggered unlocking is particularly required for high viscosity actives, which means that increased spring force is not required so much at the beginning of the autoinjector's trajectory where only the carpule 11 is to be connected to the needle 12 and the needle 12 into the body part of the patient are stabbing, but rather at the end of the sequence of motions, when it is only necessary to push the pressure pin 4 through the carpule 11.
    It also has the advantage that the kickback force, which occurs when the activator is triggered and which is perceived by patients to be unpleasant during use, is lower in the activator according to the invention than in the activators of the prior art.
    Various modifications of the aforementioned embodiments are conceivable. For example, the first coil spring 1 may be connected to the second coil spring 2 and form a one-piece double spring. This may prove advantageous in the manufacturing process of the coil spring itself and in the assembly of the activator unit. The advantage of the increased force, which act by two coil springs on the piston 15, while still maintained. It is also conceivable that the activator unit and the injection unit 9 are not carried out separately and / or screwed together, but can be connected to one another by other means or produced in one piece from the beginning.
    权利要求:
    Claims (10)
    [1]
    1. Aktivatoreinheit for an autoinjector with a substantially cylindrical housing in which an axially displaceable pressure pin is guided, which is insertable against a spring unit and locked in the inserted position by means of latching projections of a pressure pin connected to the support member, characterized in that the Spring unit comprises a first coil spring (1) and at least one further second coil spring (2) having a larger diameter than the first coil spring (1), wherein the second coil spring (2) coaxial with the first coil spring (1) is arranged.
    [2]
    2. Aktivatoreinheit according to claim 1, characterized in that the first coil spring (1) and the second coil spring (2) have substantially the same length.
    [3]
    3. Aktivatoreinheit according to claim 1 or 2, characterized in that the first coil spring (1) and the second coil spring (2) are designed as parts of a one-piece double spring.
    [4]
    4. Aktivatoreinheit according to claim 1, characterized in that the second coil spring (2) with a displaceable by the first coil spring (1) organ is held and locked, wherein the locking of the second coil spring (2) in an outer relaxation point of the first coil spring ( 1) can be unlocked.
    [5]
    5. Aktivatoreinheit according to claim 1, characterized in that the first coil spring (1) with a displaceable by the second coil spring (2) organ is held and locked, wherein the locking of the first coil spring (1) in an outer relaxation point of the second coil spring (2) is unlockable.
    [6]
    6. Aktivatoreinheit according to any one of claims 1 to 5, characterized in that the activator comprises a displaceable in the axial direction activator sleeve (7) through which the latching extensions (6) are displaceable such that the lock releasably and the pressure pin (4) the spring unit is movable.
    [7]
    7. Activator unit according to claim 6, characterized in that the activator unit has a removable safety cap (8) which has an organ which fixes the latching projections.
    [8]
    8. Activator unit according to one of claims 1 to 7, characterized in that the activator unit has at its distal end a thread or a bayonet closure, by which / which it is connectable to an injector unit (9).
    [9]
    9. Aktivatoreinheit according to claim 8, characterized in that the pressure pin (4) has on its distal end face mechanical means for breaking a seal.
    [10]
    10. autoinjector with an activator unit according to claims 1 to 9.
    类似技术:
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    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    WO2009007229A1|2007-07-06|2009-01-15|Shl Medical Ab|One shot injector with dual springs|
    WO2009063030A1|2007-11-14|2009-05-22|Shl Group Ab|Automatic injection device with actively triggered syringe withdrawal|
    WO2011048422A2|2009-10-21|2011-04-28|Owen Mumford Limited|Autoinjector|
    WO2012073035A1|2010-12-02|2012-06-07|Oval Medical Technologies Limited|Delivery mechanism for an autoinjector|
    FR1538565A|1967-07-26|1968-09-06|Automatic hypodermic syringe|
    US4031893A|1976-05-14|1977-06-28|Survival Technology, Inc.|Hypodermic injection device having means for varying the medicament capacity thereof|
    ES2191661T3|1992-01-24|2003-09-16|I Flow Corp|PLATINUM PUMP.|
    US5599309A|1993-03-24|1997-02-04|Owen Mumford Limited|Injection devices|
    YU49336B|1999-07-27|2005-07-19|Pharma Consult Ges.M.B.H.|Device for automatically injecting injection liquids|
    AT7347U1|2003-08-29|2005-02-25|Pharma Consult Ges M B H & Co|DEVICE FOR THE AUTOMATIC INJECTION OF INJECTION LIQUIDS|
    CH696421A5|2003-12-18|2007-06-15|Tecpharma Licensing Ag|Autoinjector with arresting the drug container.|
    CN102895718B|2006-09-29|2015-01-14|诺沃—诺迪斯克有限公司|An injection device with electronic detecting means|
    GB2452030A|2007-08-10|2009-02-25|Owen Mumford Ltd|Injection devices|
    EP2303366B1|2008-06-02|2019-10-02|SHL Medical AG|Medicament delivery device|
    AT506690B1|2008-06-16|2009-11-15|Pharma Consult Ges M B H & Co|INJECTION DEVICE|
    EP2451511B1|2009-07-08|2019-01-23|Novo Nordisk A/S|Auto-priming injection device|
    GB201017363D0|2010-10-14|2010-11-24|Owen Mumford Ltd|Injection devices|
    EP2489380A1|2011-02-18|2012-08-22|Sanofi-Aventis Deutschland GmbH|Injection device|US10569017B2|2013-03-15|2020-02-25|Windgap Medical, Inc.|Portable drug mixing and delivery device and associated methods|
    US9907910B2|2013-03-15|2018-03-06|Windgap Medical, Inc.|Portable drug mixing and delivery device and associated methods|
    WO2014146060A1|2013-03-15|2014-09-18|Windgap Medical, Inc.|Portable drug mixing and delivery system and method|
    AU2015305641B2|2014-08-18|2018-11-08|Windgap Medical, Inc|Portable drug mixing and delivery device and associated methods|
    US11116903B2|2014-08-18|2021-09-14|Windgap Medical, Inc|Compression seal for use with a liquid component storage vial of an auto-injector|
    US10220147B2|2015-08-13|2019-03-05|Windgap Medical, Inc.|Mixing and injection device with sterility features|
    AU2015364280A1|2014-12-18|2017-07-06|Windgap Medical, Inc.|Method and compositions for dissolving or solubilizing therapeutic agents|
    AU2016235054B2|2015-03-24|2020-07-16|Kaleo, Inc.|Devices and methods for delivering a lyophilized medicament|
    CA2990950A1|2015-06-30|2017-01-05|Kaleo, Inc.|Auto-injectors for administration of a medicament within a prefilled syringe|
    FR3039069B1|2015-07-24|2021-07-23|Nemera La Verpilliere|AUTOMATIC LIQUID PRODUCT INJECTION DEVICE INCLUDING AN INJECTION SPRING.|
    AU2017207385B2|2016-01-12|2022-02-17|Pharma Consult Ges.M.B.H.|Injection device|
    CN105688314A|2016-03-29|2016-06-22|中国人民解放军军事医学科学院实验仪器厂|Automatic injection device|
    CA3046228A1|2016-12-23|2018-06-28|Kaleo, Inc.|Medicament delivery device and methods for delivering drugs to infants and children|
    US11167087B2|2019-08-09|2021-11-09|Kaleo, Inc.|Devices and methods for delivery of substances within a prefilled syringe|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    ATA514/2013A|AT514484B1|2013-06-24|2013-06-24|Activator for an auto-injector|ATA514/2013A| AT514484B1|2013-06-24|2013-06-24|Activator for an auto-injector|
    AU2014302002A| AU2014302002B2|2013-06-24|2014-06-05|Activator for an autoinjector|
    NZ71570514A| NZ715705A|2013-06-24|2014-06-05|Activator for an autoinjector|
    KR1020167002044A| KR20160025569A|2013-06-24|2014-06-05|Activator for an autoinjector|
    RU2015152859A| RU2678410C2|2013-06-24|2014-06-05|Activator for automatic injector|
    CN201480035765.7A| CN105324141B|2013-06-24|2014-06-05|Activator for automatic injector|
    CA2916317A| CA2916317C|2013-06-24|2014-06-05|Activator for an autoinjector|
    PCT/AT2014/000117| WO2014205463A1|2013-06-24|2014-06-05|Activator for an autoinjector|
    US14/900,923| US10105499B2|2013-06-24|2014-06-05|Activator for an autoinjector|
    JP2016520183A| JP6525972B2|2013-06-24|2014-06-05|Actuator for self-injector|
    KR1020217013119A| KR20210050600A|2013-06-24|2014-06-05|Activator for an autoinjector|
    BR112015032296A| BR112015032296A2|2013-06-24|2014-06-05|activator for an autoinjector|
    PL14734374T| PL3013392T3|2013-06-24|2014-06-05|Activator for an automatic injection device|
    EP14734374.3A| EP3013392B1|2013-06-24|2014-06-05|Activator for an automatic injection device|
    IL243241A| IL243241D0|2013-06-24|2015-12-20|Activator for an autoinjector|
    SA515370306A| SA515370306B1|2013-06-24|2015-12-23|Activator for an autoinjector|
    ZA2016/00441A| ZA201600441B|2013-06-24|2016-01-20|Activator for an autoinjector|
    HK16112423.4A| HK1224235A1|2013-06-24|2016-10-28|Activator for an autoinjector|
    US16/156,389| US10780233B2|2013-06-24|2018-10-10|Activator for an autoinjector|
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